Article

Generative AI designs functional thiolation domains for reprogramming non-ribosomal peptide synthetases

2026-03-04

Abstract excerpt

Large language models and generative protein design promise to accelerate biotechnology, but it remains unclear whether they can engineer dynamic megasynth(et)ases whose activity depends on transient, context-specific domain interfaces. Non-ribosomal peptide synthetases (NRPSs) are an especially demanding target, yet a high-value one because they produce many clinically important natural products and offer a route...

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Literature Corpus work: c5d4e7a3-0cc7-52f2-8c90-0edc9b644419
DOI: 10.64898/2026.03.03.709401

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