Article
Creating functional engineered variants of the single-module non-ribosomal peptide synthetase IndC by T domain exchange.
Molecular bioSystems - 1 Jul 2014
Beer Ralf, Herbst Konrad, Ignatiadis Nikolaos, Kats Ilia, Adlung Lorenz, Meyer Hannah, Niopek Dominik, Christiansen Tania, Georgi Fanny, Kurzawa Nils, Meichsner Johanna, Rabe Sophie, Riedel Anja, Sachs Joshua, Schessner Julia, Schmidt Florian, Walch Philipp, Niopek Katharina, Heinemann Tim, Eils Roland, Di Ventura Barbara
Abstract excerpt
Non-ribosomal peptide synthetases (NRPSs) are enzymes that catalyze ribosome-independent production of small peptides, most of which are bioactive. NRPSs act as peptide assembly lines where individual, often interconnected modules each incorporate a specific amino acid into the nascent chain. The modules themselves consist of several domains that function in the activation, modification and condensation of the...
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