Article

Elucidating the molecular programming of a nonlinear nonribosomal peptide synthetase responsible for fungal siderophore biosynthesis

2022-10-10

Abstract excerpt

<h4>ABSTRACT</h4> Siderophores belonging to the ferrichrome family are essential for the viability of fungal species and play a key role for virulence of numerous pathogenic fungi. Despite their biological significance, our understanding of how these iron-chelating cyclic hexapeptides are assembled by non-ribosomal peptide synthetase (NRPS) assembly lines remains poorly understood, primarily due to the nonlineari...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9035a108-441d-514d-b3e1-a7bf1de5c030
DOI: 10.1101/2022.10.10.511241

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Elucidating the molecular programming of a nonlinear nonribosomal peptide synthetase responsible for fungal siderophore biosynthesisDOI 10.1101/2022.10.10.511241Read

Evolutionary and functional analysis of an NRPS condensation domain integrates β-lactam, ᴅ-amino acid, and dehydroamino acid synthesisSemantic proximity Read

Expanding the substrate selectivity of the fimsbactin biosynthetic adenylation domain, FbsHSemantic proximity Read

Targeting Siderophore Biosynthesis to Thwart Microbial GrowthSemantic proximity Read

High-throughput engineering and modification of non-ribosomal peptide synthetases based on Golden Gate assemblySemantic proximity Read

Biosynthetic engineering of nonribosomal peptide synthetases.Semantic proximity Read

Precise Probing of Residue Roles by NRPS Code Swapping: Mutation, Enzymatic Characterization, Modeling, and Substrate Promiscuity of Aryl Acid Adenylation Domains.Semantic proximity Read

Discovery of lydiamycin A biosynthetic gene cluster in the plant pathogen <i>Rhodococcus fascians</i> guides structural revision and identification of molecular targetSemantic proximity Read

Evolution Inspired Engineering of MegasynthetasesSemantic proximity Read

Cell-Free Biosynthesis to Evaluate Lasso Peptide Formation and Enzyme-Substrate ToleranceSemantic proximity Read

Mutations in Dynamic Structural Elements Alter the Kinetics and Fidelity of the Multifunctional Class II Lanthipeptide Synthetase, HalM2.Semantic proximity Read

Mixing and matching siderophore clusters: structure and biosynthesis of serratiochelins from Serratia sp. V4.Semantic proximity Read

Evolution of Siderophore Pathways in Human Pathogenic BacteriaSemantic proximity Read