Article

Prioritization of antimicrobial targets by CRISPR-based oligo recombineering

2021-02-04

Abstract excerpt

<h4>Summary</h4> Nucleophilic amino acids are important in covalent drug development yet underutilized as antimicrobial targets. Over recent years, several chemoproteomic technologies have been developed to mine chemically-accessible residues via their intrinsic reactivity toward electrophilic probes. However, these approaches cannot discern which reactive sites contribute to protein function and should therefore...

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Literature Corpus work: ea1595cc-ade0-5d86-88ce-0ec6c560f2e1
DOI: 10.1101/2021.02.04.429737

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