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Bio-inspired engineering of thiopeptide antibiotics advances the expansion of molecular diversity and utility.

Current opinion in biotechnology - 1 Dec 2017

Lin Zhi, He Qingli, Liu Wen

Abstract excerpt

Thiopeptide antibiotics, which are a class of sulfur-rich and highly modified peptide natural products, exhibit a wide variety of important biological properties. These antibiotics are ribosomally synthesized and arise from post-translational modifications, exemplifying a process through which nature develops the structural complexity from Ser/Thr and Cys-rich precursor peptides. Following a brief review of the...

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PMID: 28672170
DOI: 10.1016/j.copbio.2017.06.008

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