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Article

TLR7 influences germinal center selection in murine SLE.

PloS one - 1 Jan 2015

Boneparth Alexis, Huang Weiqing, Bethunaickan Ramalingam, Woods Megan, Sahu Ranjit, Arora Shitij, Akerman Meredith, Lesser Martin, Davidson Anne

Abstract excerpt

TLR7 enhances germinal center maturation and migration of B cells to the dark zone where proliferation and somatic hypermutation occur. Our goal was to determine how Tlr7 dose influences selection of the autoreactive B cell repertoire in NZW/BXSB. Yaa mice bearing the site-directed heavy chain transgene 3H9 that encodes for the TLR7 regulated anti-CL response. To create a physiologic setting in which autoreactive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25794167
DOI: 10.1371/journal.pone.0119925
PMCID: PMC4368537

Genes

TLR7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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