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TCRβ Sequencing Reveals Spatial and Temporal Evolution of Clonal CD4 T cell Responses in a Breach of Tolerance Model of Inflammatory Arthritis

2020-11-15

Abstract excerpt

<h4>ABSTRACT</h4> Effective tolerogenic intervention in Rheumatoid Arthritis (RA) will rely upon understanding the evolution of articular antigen specific CD4 T cell responses. TCR clonality of endogenous CD4 T cell infiltrates in early inflammatory arthritis was assessed to monitor evolution of the TCR repertoire in the inflamed joint and associated lymph node (LN). Mouse models of antigen-induced breach of self...

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Literature Corpus work
0425520c-ec0a-5a34-9ddd-a9c6d762a750
DOI
10.1101/2020.11.15.383539
Open publication

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TCRβ Sequencing Reveals Spatial and Temporal Evolution of Clonal CD4 T cell Responses in a Breach of Tolerance Model of Inflammatory ArthritisDOI 10.1101/2020.11.15.383539
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