Article
CD4+ virtual memory: Antigen-inexperienced T cells reside in the naïve, regulatory, and memory T cell compartments at similar frequencies, implications for autoimmunity.
Journal of autoimmunity - 1 Feb 2017
Marusina Alina I, Ono Yoko, Merleev Alexander A, Shimoda Michiko, Ogawa Hiromi, Wang Elizabeth A, Kondo Kayo, Olney Laura, Luxardi Guillaume, Miyamura Yoshinori, Yilma Tilahun D, Villalobos Itzel Bustos, Bergstrom Jennifer W, Kronenberg Daniel G, Soulika Athena M, Adamopoulos Iannis E, Maverakis Emanual
Abstract excerpt
It is widely accepted that central and effector memory CD4+ T cells originate from naïve T cells after they have encountered their cognate antigen in the setting of appropriate co-stimulation. However, if this were true the diversity of T cell receptor (TCR) sequences within the naïve T cell compartment should be far greater than that of the memory T cell compartment, which is not supported by TCR sequencing...
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