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Article

TCRβ Sequencing Reveals Spatial and Temporal Evolution of Clonal CD4 T Cell Responses in a Breach of Tolerance Model of Inflammatory Arthritis.

Frontiers in immunology - 1 Jan 2021

Al Khabouri Shaima, Benson Robert A, Prendergast Catriona T, Gray Joshua I, Otto Thomas D, Brewer James M, Garside Paul

Abstract excerpt

Effective tolerogenic intervention in Rheumatoid Arthritis (RA) will rely upon understanding the evolution of articular antigen specific CD4 T cell responses. TCR clonality of endogenous CD4 T cell infiltrates in early inflammatory arthritis was assessed to monitor evolution of the TCR repertoire in the inflamed joint and associated lymph node (LN). Mouse models of antigen-induced breach of self-tolerance and...

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Share to Arthritis, Experimental
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Disease Progression

Share to Genes, T-Cell Receptor beta

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Source

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Identifiers

PMID: 33986757
DOI: 10.3389/fimmu.2021.669856
PMCID: PMC8110912

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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TCRβ Sequencing Reveals Spatial and Temporal Evolution of Clonal CD4 T Cell Responses in a Breach of Tolerance Model of Inflammatory Arthritis.PMID 33986757Read ↗

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