Article
Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels.
Development (Cambridge, England) - 1 Jun 2002
Roman Beth L, Pham Van N, Lawson Nathan D, Kulik Magdalena, Childs Sarah, Lekven Arne C, Garrity Deborah M, Moon Randall T, Fishman Mark C, Lechleider Robert J, Weinstein Brant M
Abstract excerpt
The zebrafish mutant violet beauregarde (vbg) can be identified at two days post-fertilization by an abnormal circulation pattern in which most blood cells flow through a limited number of dilated cranial vessels and fail to perfuse the trunk and tail. This phenotype cannot be explained by caudal vessel abnormalities or by a defect in cranial vessel patterning, but instead stems from an increase in endothelial...
Topics
- Activin Receptors
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Blood Vessels
- Cerebrovascular Circulation
- Chromosome Mapping
- DNA-Binding Proteins
- Embryo, Nonmammalian
- Gene Expression Regulation, Developmental
- Head
- Humans