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Article

Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.

Nature cell biology - 1 Jun 2017

Sugden Wade W, Meissner Robert, Aegerter-Wilmsen Tinri, Tsaryk Roman, Leonard Elvin V, Bussmann Jeroen, Hamm Mailin J, Herzog Wiebke, Jin Yi, Jakobsson Lars, Denz Cornelia, Siekmann Arndt F

Abstract excerpt

The hierarchical organization of properly sized blood vessels ensures the correct distribution of blood to all organs of the body, and is controlled via haemodynamic cues. In current concepts, an endothelium-dependent shear stress set point causes blood vessel enlargement in response to higher flow rates, while lower flow would lead to blood vessel narrowing, thereby establishing homeostasis. We show that during...

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Identifiers

PMID: 28530658
DOI: 10.1038/ncb3528
PMCID: PMC5455977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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