Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues.

Angiogenesis - 10 Dec 2024

Diwan Zeenat, Kang Jia, Tsztoo Emma, Siekmann Arndt F

Abstract excerpt

Hemodynamic cues are thought to control blood vessel hierarchy through a shear stress set point, where flow increases lead to blood vessel diameter expansion, while decreases in blood flow cause blood vessel narrowing. Aberrations in blood vessel diameter control can cause congenital arteriovenous malformations (AVMs). We show in zebrafish embryos that while arteries behave according to the shear stress set point...

Topics

Animals
Zebrafish
Signal Transduction
Hemodynamics
Zebrafish Proteins
Endoglin
Veins
Cell Size
Arteriovenous Malformations
Activin Receptors, Type II
Endothelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 39656297
DOI: 10.1007/s10456-024-09955-3
PMCID: PMC11632009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues.PMID 39656297Read ↗

Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues and limits ribosomal biogenesisSemantic proximity Read ↗

Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.Semantic proximity Read ↗

Interaction between alk1 and blood flow in the development of arteriovenous malformationsSemantic proximity Read ↗

Reversal of vein of Galen aneurysmal malformation by stimulation of flow-mediated vessel fusionSemantic proximity Read ↗

Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels.Semantic proximity Read ↗

PIEZO1 overexpression in hereditary hemorrhagic telangiectasia arteriovenous malformationsSemantic proximity Read ↗

Plxnd1-mediated mechanosensing of blood flow controls the caliber of the Dorsal Aorta via the transcription factor Klf2Semantic proximity Read ↗

Blood flow regulates <i>acvrl1</i> transcription via ligand-dependent Alk1 activitySemantic proximity Read ↗

Loss of distinct arterial and venous boundaries in mice lacking endoglin, a vascular-specific TGFbeta coreceptor.Semantic proximity Read ↗

Lats1/2 are essential for developmental vascular remodeling and biomechanical adaptation to shear stressSemantic proximity Read ↗

Endothelial cell biology of Endoglin in hereditary hemorrhagic telangiectasia.Semantic proximity Read ↗

Defective fluid shear stress mechanotransduction mediates hereditary hemorrhagic telangiectasiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.