Article

Polygenic scores for disease risk are not associated with clinical outcomes in Parkinson’s disease

2025-02-03

Abstract excerpt

Polygenic risk scores (PRS) in Parkinson’s disease (PD) are associated with disease risk. Recently, pathway-specific PRS have been created to take advantage of annotations inking variants to biological pathways or cell types. Here, we investigated 8 biological pathways or regions of open chromatin using pathway-specific PRS: alpha-synuclein pathway, adaptive immunity, innate immunity, lysosomal pathway1, endocytic...

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Literature Corpus work: 36a1c001-aa22-54d7-8a7c-f31a091550c6
DOI: 10.1101/2025.01.31.25321395

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