Article

Large-scale pathway-specific polygenic risk, transcriptomic community networks and functional inferences in Parkinson disease

2020-05-06

Abstract excerpt

<h4>ABSTRACT</h4> Polygenic inheritance plays a central role in Parkinson disease (PD). A priority in elucidating PD etiology lies in defining the biological basis of genetic risk. Unraveling how risk leads to disruption will yield disease-modifying therapeutic targets that may be effective. Here, we utilized a high-throughput and hypothesis-free approach to determine biological pathways underlying PD using the l...

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Literature Corpus work: f208419a-e945-51bc-b92f-9e24934c760f
DOI: 10.1101/2020.05.05.079228

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