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Article

Heritability Enrichment Implicates Microglia in Parkinson's Disease Pathogenesis.

Annals of neurology - 1 May 2021

Andersen Maren Stolp, Bandres-Ciga Sara, Reynolds Regina H, Hardy John, Ryten Mina, Krohn Lynne, Gan-Or Ziv, Holtman Inge R, Pihlstrøm Lasse

Abstract excerpt

OBJECTIVE: Understanding how different parts of the immune system contribute to pathogenesis in Parkinson's disease is a burning challenge with important therapeutic implications. We studied enrichment of common variant heritability for Parkinson's disease stratified by immune and brain cell types. METHODS: We used summary statistics from the most recent meta-analysis of genomewide association studies in...

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PMID: 33502028
DOI: 10.1002/ana.26032
PMCID: PMC9017316

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