Article

Genome-Wide Polygenic Risk Score Identifies Individuals at Elevated Parkinson’s Disease Risk

2020-10-20

Abstract excerpt

<h4>SUMMARY</h4> Parkinson’s Disease (PD) is the second most common and fastest-growing neurological disorder. Polygenic Risk Scores (PRS) using hundreds to thousands of PD-associated variants support polygenic heritability. Here, for the first time, we apply a genome-wide polygenic risk score approach using 6.2 million variants to compute a PD genome-wide polygenic risk score (PD-GPRS) via the LDPred algorithm. P...

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Literature Corpus work: f2de2315-73f8-5ee1-951c-bcf2d2d537fc
DOI: 10.1101/2020.10.16.20212944

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