Article

DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression

2021-07-02

Abstract excerpt

Chronic myeloproliferative neoplasms (MPNs) exhibit a propensity for transformation to secondary acute myeloid leukemia (sAML), for which the underlying mechanisms remain poorly understood, resulting in limited treatment options and dismal clinical outcomes. Here, we performed bulk transcriptome profiling accompanied by single cell RNA-sequencing on CD34+ stem/progenitor cells from serial patient samples obtained...

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Literature Corpus work: 71ec2278-2832-5757-8308-a63fc5ebf64d
DOI: 10.1101/2021.06.27.449656

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