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<i>N</i> <sup>6</sup> -methyladenosine (m <sup>6</sup> A) and reader protein YTHDF2 enhance innate immune response by mediating DUSP1 mRNA degradation and activating mitogen-activated protein kinases during bacterial and viral infections

2022-12-02

Abstract excerpt

Mitogen-activated protein kinases (MAPKs) play critical roles in the induction of numerous cytokines, chemokines, and inflammatory mediators that mobilize the immune system to counter pathogenic infections. Dual-specificity phosphatase-1 (DUSP1) is a member of dual-specificity phosphatases, which inactivates MAPKs through a negative feedback mechanism. Here we report that in response to viral and bacterial infecti...

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Literature Corpus work
30b0cdae-6098-574d-8072-9a5bfab3cb39
DOI
10.1101/2022.12.01.518805
Open publication

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<i>N</i> <sup>6</sup> -methyladenosine (m <sup>6</sup> A) and reader protein YTHDF2 enhance innate immune response by mediating DUSP1 mRNA degradation and activating mitogen-activated protein kinases during bacterial and viral infectionsDOI 10.1101/2022.12.01.518805
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