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Article

Enhanced MAPK signaling induced by CSF3R mutants confers dependence to DUSP1 for leukemic transformation.

Blood advances - 11 Jun 2024

Kesarwani Meenu, Kincaid Zachary, Azhar Mohammad, Azam Mohammad

Abstract excerpt

ABSTRACT: Elevated MAPK and the JAK-STAT signaling play pivotal roles in the pathogenesis of chronic neutrophilic leukemia and atypical chronic myeloid leukemia. Although inhibitors targeting these pathways effectively suppress the diseases, they fall short in providing enduring remission, largely attributed to the cytostatic nature of these drugs. Even combinations of these drugs are ineffective in achieving...

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Share to Apoptosis
Share to Cell Transformation, Neoplastic
Share to Gene Expression Regulation, Leukemic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to MAP Kinase Signaling System

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Share to Receptors, Colony-Stimulating Factor

Source

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Identifiers

PMID: 38531054
DOI: 10.1182/bloodadvances.2023010830
PMCID: PMC11176961

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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