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Article

MAPK-negative feedback regulation confers dependence to JAK2V617F signaling.

Leukemia - 1 Aug 2023

Kesarwani Meenu, Kincaid Zachary, Azhar Mohammad, Menke Jacob, Schwieterman Joshua, Ansari Sekhu, Reaves Angela, Deininger Michael E, Levine Ross, Grimes H Leighton, Azam Mohammad

Abstract excerpt

Despite significant advances in developing selective JAK2 inhibitors, JAK2 kinase inhibitor (TKI) therapy is ineffective in suppressing the disease. Reactivation of compensatory MEK-ERK and PI3K survival pathways sustained by inflammatory cytokine signaling causes treatment failure. Concomitant inhibition of MAPK pathway and JAK2 signaling showed improved in vivo efficacy compared to JAK2 inhibition alone but...

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Source

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Identifiers

PMID: 37430058
DOI: 10.1038/s41375-023-01959-0
PMCID: PMC10976185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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