Article

Elucidating oncogenic mechanisms in human B cell malignancies

2018-01-01

Abstract excerpt

This study consists of two pieces of work investigating haematological malignancies; Acute Lymphoblastic Leukaemia (ALL) and Diffuse Large B Cell Lymphoma (DLBCL). Firstly, Pre-B ALL represents the most common paediatric malignancy and despite increasingly improved outcomes for patients, ~ 20% of all patients diagnosed with ALL relapse. Activating mutations in the RAS pathway are common (~50%) and result in hypera...

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Literature Corpus work: 97d3455a-c9fb-582b-92a2-38a5dc055310
DOI: 10.17863/cam.32382

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