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Novel spirocyclic dimer, SpiD3, targets chronic lymphocytic leukemia survival pathways with potent preclinical effects

2024-02-03

Abstract excerpt

<h4>ABSTRACT</h4> Chronic lymphocytic leukemia (CLL) cell survival and growth is fueled by the induction of B-cell receptor (BCR) signaling within the tumor microenvironment (TME) driving activation of NF- κB signaling and the unfolded protein response (UPR). Malignant cells have higher basal levels of UPR posing a unique therapeutic window to combat CLL cell growth using pharmacological agents that induce accumu...

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Literature Corpus work
3cbbdd4d-a445-52b3-b881-e1585f9230bb
DOI
10.1101/2024.01.31.578283
Open publication

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Novel spirocyclic dimer, SpiD3, targets chronic lymphocytic leukemia survival pathways with potent preclinical effectsDOI 10.1101/2024.01.31.578283
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