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Article

Cyclin-Dependent Kinase Inhibitor P1446A Induces Apoptosis in a JNK/p38 MAPK-Dependent Manner in Chronic Lymphocytic Leukemia B-Cells.

PloS one - 1 Jan 2015

Paiva Cody, Godbersen J Claire, Soderquist Ryan S, Rowland Taylor, Kilmarx Sumner, Spurgeon Stephen E, Brown Jennifer R, Srinivasa Sreesha P, Danilov Alexey V

Abstract excerpt

CDK (cyclin-dependent kinase) inhibitors have shown remarkable activity in CLL, where its efficacy has been linked to inhibition of the transcriptional CDKs (7 and 9) and deregulation of RNA polymerase and short-lived pro-survival proteins such as MCL1. Furthermore, ER (endoplasmic reticulum) stress has been implicated in CDK inhibition in CLL. Here we conducted a pre-clinical study of a novel orally active...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to JNK Mitogen-Activated Protein Kinases

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to p38 Mitogen-Activated Protein Kinases

Share to Proto-Oncogene Proteins c-bcl-2

Share to Stromal Cells

Share to Unfolded Protein Response

Source

Open in PubMed Open full text

Identifiers

PMID: 26606677
DOI: 10.1371/journal.pone.0143685
PMCID: PMC4659573

Genes

MCL1
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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