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Article

Activation of 2' 5'-oligoadenylate synthetase by stem loops at the 5'-end of the West Nile virus genome.

PloS one - 1 Jan 2014

Deo Soumya, Patel Trushar R, Dzananovic Edis, Booy Evan P, Zeid Khalid, McEleney Kevin, Harding Stephen E, McKenna Sean A

Abstract excerpt

West Nile virus (WNV) has a positive sense RNA genome with conserved structural elements in the 5' and 3' -untranslated regions required for polyprotein production. Antiviral immunity to WNV is partially mediated through the production of a cluster of proteins known as the interferon stimulated genes (ISGs). The 2' 5'-oligoadenylate synthetases (OAS) are key ISGs that help to amplify the innate immune response....

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Identifiers

PMID: 24651762
DOI: 10.1371/journal.pone.0092545
PMCID: PMC3961380

Genes

OAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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