Article
A prenylated dsRNA sensor protects against severe COVID-19.
Science (New York, N.Y.) - 29 Oct 2021
Wickenhagen Arthur, Sugrue Elena, Lytras Spyros, Kuchi Srikeerthana, Noerenberg Marko, Turnbull Matthew L, Loney Colin, Herder Vanessa, Allan Jay, Jarmson Innes, Cameron-Ruiz Natalia, Varjak Margus, Pinto Rute M, Lee Jeffrey Y, Iselin Louisa, Palmalux Natasha, Stewart Douglas G, Swingler Simon, Greenwood Edward J D, Crozier Thomas W M, Gu Quan, Davies Emma L, Clohisey Sara, Wang Bo, Trindade Maranhão Costa Fabio, Freire Santana Monique, de Lima Ferreira Luiz Carlos, Murphy Lee, Fawkes Angie, Meynert Alison, Grimes Graeme, Da Silva Filho Joao Luiz, Marti Matthias, Hughes Joseph, Stanton Richard J, Wang Eddie C Y, Ho Antonia, Davis Ilan, Jarrett Ruth F, Castello Alfredo, Robertson David L, Semple Malcolm G, Openshaw Peter J M, Palmarini Massimo, Lehner Paul J, Baillie J Kenneth, Rihn Suzannah J, Wilson Sam J
Abstract excerpt
Inherited genetic factors can influence the severity of COVID-19, but the molecular explanation underpinning a genetic association is often unclear. Intracellular antiviral defenses can inhibit the replication of viruses and reduce disease severity. To better understand the antiviral defenses relevant to COVID-19, we used interferon-stimulated gene (ISG) expression screening to reveal that 2′-5′-oligoadenylate...
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