Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Astrocyte Reactivity Polygenic Risk Score May Predict Cognitive Decline in Alzheimer's Disease.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2025

Phillips Jared M, Schneider Julie A, Bennett David A, Crane Paul K, Risacher Shannon L, Saykin Andrew J, Dumitrescu Logan C, Hohman Timothy J

Abstract excerpt

Alzheimer's disease (AD) is a polygenic disorder with a prolonged prodromal phase, complicating early diagnosis. Recent research indicates that increased astrocyte reactivity is associated with a higher risk of pathogenic tau accumulation, particularly in amyloid-positive individuals. However, few clinical tools are available to predict which individuals are likely to exhibit elevated astrocyte activation and,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Peptides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Astrocytes

Share to Cognitive Dysfunction

Share to Genetic Risk Score

Share to Multifactorial Inheritance

Share to Peptide Fragments

Share to tau Proteins

Source

Identifiers

PMID: 39670391

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Astrocyte Reactivity Polygenic Risk Score May Predict Cognitive Decline in Alzheimer's Disease.PMID 39670391Read ↗

Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease processes in Alzheimer’s diseaseSemantic proximity Read ↗

Cell-type-specific Alzheimer’s disease polygenic risk scores are associated with distinct disease processes in Alzheimer’s diseaseSemantic proximity Read ↗

Testing a polygenic risk score for morphological microglial activation in Alzheimer’s disease and agingSemantic proximity Read ↗

APOE genotype and astrocyte activity collectively influence AD biomarkers and Aβ burden.Semantic proximity Read ↗

Relationship between BrainAge Polygenetic Risk Score and plasma biomarkers in the A4/LEARN studiesSemantic proximity Read ↗

Alzheimer’s polygenic risk scores, APOE, Alzheimer’s disease risk, and dementia-related blood biomarker levels in a population-based cohort study followed over 17 yearsSemantic proximity Read ↗

Polygenic effect on accelerated tau pathology accumulation in Alzheimer’s disease: implications for patient selection in clinical trialsSemantic proximity Read ↗

Astrocyte biomarker signatures of amyloid-β and tau pathologies in Alzheimer’s diseaseSemantic proximity Read ↗

Association of plasma glial fibrillary acidic protein and APOE-ε4 with Alzheimer's disease.Semantic proximity Read ↗

Genetic Predisposition to Hippocampal Atrophy and Risk of Amnestic Mild Cognitive Impairment and Alzheimer’s DementiaSemantic proximity Read ↗

Predictability of polygenic risk score for progression to dementia and its interaction with APOE ε4 in mild cognitive impairment.Semantic proximity Read ↗

Changes in iPSC-astrocyte morphology reflect Alzheimer’s disease patient clinical markersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.