Article

Complexity of enhancer networks predicts cell identity and disease genes revealed by single-cell multi-omics analysis

2022-05-20

Abstract excerpt

Many enhancers exist as clusters in the genome and control cell identity and disease genes; however, the underlying mechanism remains largely unknown. Here, we introduce an algorithm, eNet, to build enhancer networks by integrating single-cell chromatin accessibility and gene expression profiles. Enhancer network is a gene regulation model we proposed that not only delineates the mapping between enhancers and targ...

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Literature Corpus work: c19d2b99-f362-5188-ad88-e3efb5b2ef4e
DOI: 10.1101/2022.05.20.492770

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