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Article

Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points

28 May 2018

Abstract excerpt

BACKGROUND: Enhancers and promoters are cis-acting regulatory elements associated with lineage-specific gene expression. Previous studies showed that different categories of active regulatory elements are in regions of open chromatin, and each category is associated with a specific subset of post-translationally marked histones. These regulatory elements are systematically activated and repressed to promote...

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PMID: 29807547
DOI: 10.1186/s13072-018-0195-z

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