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Article

BMI1 maintains the Treg epigenomic landscape to prevent inflammatory bowel disease

14 Jun 2021

Abstract excerpt

FOXP3+ Tregs are expanded within the inflamed intestine of human Crohn's disease, yet FOXP3-mediated gene repression within these cells is lost. The polycomb repressive complexes play a role in FOXP3 target gene regulation, but deeper mechanistic insight is incomplete. We have now specifically identified the polycomb-repressive complex 1 (PRC1) family member, BMI1 in the regulation of a proinflammatory enhancer...

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PMID: 34128475
DOI: 10.1172/jci140755

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