Article

The loss of DNA polymerase epsilon accessory subunits POLE3-POLE4 leads to BRCA1-independent PARP inhibitor sensitivity

2023-09-22

Abstract excerpt

<h4>ABSTRACT</h4> The clinical success of PARP1/2 inhibitors prompts the expansion of their applicability beyond homologous recombination deficiency. Here, we demonstrate that the loss of the accessory subunits of DNA polymerase epsilon, POLE3 and POLE4, sensitizes cells to PARP inhibitors. We show that the sensitivity of POLE4 knockouts is not due to a compromised response to DNA damage or homologous recombinati...

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Literature Corpus work: 365df051-6e61-5903-bda7-cc9cdd96773f
DOI: 10.1101/2023.09.21.558850

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