Article

Loss of Nuclear DNA Ligase III Reverts PARP Inhibitor Resistance in BRCA1/53BP1 Double-deficient Cells by Exposing ssDNA Gaps

2021-03-24

Abstract excerpt

<h4>SUMMARY</h4> Inhibitors of poly(ADP-ribose) (PAR) polymerase (PARPi) have entered the clinic for the treatment of homologous recombination (HR)-deficient cancers. Despite the success of this approach, preclinical and clinical research with PARPi has revealed multiple resistance mechanisms, highlighting the need for identification of novel functional biomarkers and combination treatment strategies. Functional...

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Literature Corpus work: 1e9d4c5d-36ad-5f85-a403-d9fce9aa25dd
DOI: 10.1101/2021.03.24.436323

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