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Article

PARP inhibitors suppress tumours via centrosome error-induced senescence independent of DNA damage response.

EBioMedicine - 1 May 2024

Yue Wei, Li Xinyu, Zhan Xiaolu, Wang Lei, Ma Jihong, Bi Meiyu, Wang Qilong, Gu Xiaoyang, Xie Bingteng, Liu Tong, Guo Hongyan, Zhu Xin, Song Chen, Qiao Jie, Li Mo

Abstract excerpt

BACKGROUND: Poly(ADP-ribose) polymerase (PARP) inhibitors have emerged as promising chemotherapeutic drugs primarily against BRCA1/2-associated tumours, known as synthetic lethality. However, recent clinical trials reported patients' survival benefits from PARP inhibitor treatments, irrelevant to homologous recombination deficiency. Therefore, revealing the therapeutic mechanism of PARP inhibitors beyond DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 38640836
DOI: 10.1016/j.ebiom.2024.105129
PMCID: PMC11052917

Genes

BRCA1
PARP2
PARP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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