Article

Deficiency in POLE exonuclease causes synthetic lethality in highly aneuploid cancer cells

2025-07-21

Abstract excerpt

<h4>Summary</h4> Aneuploidy is a hallmark of cancer and is associated with drug resistance and poor clinical outcomes across diverse cancer types. However, no therapies have been clinically established to target highly aneuploid tumors. By analyzing a real-world dataset comprising nearly half a million tumor samples subjected to comprehensive genomic profiling, we identified a striking mutual exclusivity between...

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Literature Corpus work: 2f24be37-c347-5ea9-8368-1f66e8b5f0e8
DOI: 10.1101/2025.07.16.665237

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