Article
Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis.
Molecular cell - 17 May 2018
Bellelli Roberto, Borel Valerie, Logan Clare, Svendsen Jennifer, Cox Danielle E, Nye Emma, Metcalfe Kay, O'Connell Susan M, Stamp Gordon, Flynn Helen R, Snijders Ambrosius P, Lassailly François, Jackson Andrew, Boulton Simon J
Abstract excerpt
DNA polymerase ε (POLE) is a four-subunit complex and the major leading strand polymerase in eukaryotes. Budding yeast orthologs of POLE3 and POLE4 promote Polε processivity in vitro but are dispensable for viability in vivo. Here, we report that POLE4 deficiency in mice destabilizes the entire Polε complex, leading to embryonic lethality in inbred strains and extensive developmental abnormalities, leukopenia,...
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