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Article

Human-specific <i>ARHGAP11B</i> is necessary and sufficient for human-type basal progenitor levels in primate brain organoids

2020-10-01

Abstract excerpt

Based on studies in various animal models, including developing ferret neocortex (Kalebic et al., 2018), the human-specific gene ARHGAP11B has been implicated in human neocortex expansion. However, the extent of its contribution to this expansion during primate evolution is unknown. Here we addressed this issue by genetic manipulation of ARHGAP11B levels and function in chimpanzee and human cerebral organoids. In...

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Literature Corpus work
36585668-c31a-5a1e-8727-564fcc58368e
DOI
10.1101/2020.10.01.322792
Open publication

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Human-specific <i>ARHGAP11B</i> is necessary and sufficient for human-type basal progenitor levels in primate brain organoidsDOI 10.1101/2020.10.01.322792
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