Article

Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortex

2017-11-28

Abstract excerpt

To understand the molecular basis underlying the expansion of the neocortex during primate, and notably human, evolution, it is essential to identify the genes that are particularly active in the neural stem and progenitor cells of developing neocortex. Here, we have used existing transcriptome datasets to carry out a comprehensive screen for protein-coding genes preferentially expressed in progenitors of fetal hu...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a4614926-9ff1-5758-b4bc-aeb6eb9acf12
DOI: 10.1101/225722

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Evolution and cell-type specificity of human-specific genes preferentially expressed in progenitors of fetal neocortexDOI 10.1101/225722Read

Orthogonal Modes of Gene Expression Evolution Shape Human Neocortical Development and Disease VulnerabilitySemantic proximity Read

Comparative single-cell regulome reveals evolutionary innovations in neural progenitor cells during primate corticogenesisSemantic proximity Read

A single cell transcriptomic analysis of human neocortical developmentSemantic proximity Read

Human-specific morphoregulatory signatures in basal radial glia characterize neocortex evolutionSemantic proximity Read

Developmental signaling reveals functionally enriched human-specific gene regulation in telencephalic progenitorsSemantic proximity Read

Establishing Cerebral Organoids as Models of Human-Specific Brain EvolutionSemantic proximity Read

Evolutionarily informed gene sets reveal conserved and lineage-modified transcriptional programs during vertebrate forebrain evolutionSemantic proximity Read

Developmental gene expression patterns driving species-specific cortical featuresSemantic proximity Read

Single-cell-resolution transcriptome map of human, chimpanzee, bonobo, and macaque brainsSemantic proximity Read

Single-cell multiomics atlas of organoid development uncovers longitudinal molecular programs of cellular diversification of the human cerebral cortexSemantic proximity Read

Human Accelerated Regions regulate gene networks implicated in apical-to-basal neural progenitor fate transitionsSemantic proximity Read

Single-cell genomic atlas of great ape cerebral organoids uncovers human-specific features of brain developmentSemantic proximity Read