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The growth factor EPIREGULIN promotes basal progenitor cell proliferation in the developing neocortex

21 Mar 2024

Abstract excerpt

Neocortex expansion during evolution is linked to higher numbers of neurons, which are thought to result from increased proliferative capacity and neurogenic potential of basal progenitor cells during development. Here, we show that EREG, encoding the growth factor EPIREGULIN, is expressed in the human developing neocortex and in gorilla cerebral organoids, but not in the mouse neocortex. Addition of EPIREGULIN...

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PMID: 38514807
DOI: 10.1038/s44318-024-00068-7

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