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Article

A single splice site mutation in human-specific ARHGAP11B causes basal progenitor amplification.

Science advances - 1 Dec 2016

Florio Marta, Namba Takashi, Pääbo Svante, Hiller Michael, Huttner Wieland B

Abstract excerpt

The gene ARHGAP11B promotes basal progenitor amplification and is implicated in neocortex expansion. It arose on the human evolutionary lineage by partial duplication of ARHGAP11A, which encodes a Rho guanosine triphosphatase-activating protein (RhoGAP). However, a lack of 55 nucleotides in ARHGAP11B mRNA leads to loss of RhoGAP activity by GAP domain truncation and addition of a human-specific carboxy-terminal...

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Identifiers

PMID: 27957544
DOI: 10.1126/sciadv.1601941
PMCID: PMC5142801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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