Article

Proneural genes define ground state rules to regulate neurogenic patterning and cortical folding

2020-09-22

Abstract excerpt

<h4>SUMMARY</h4> Transition from smooth, lissencephalic brains to highly-folded, gyrencephalic structures is associated with neuronal expansion and breaks in neurogenic symmetry. Here we show that Neurog2 and Ascl1 proneural genes regulate cortical progenitor cell differentiation through cross-repressive interactions to sustain neurogenic continuity in a lissencephalic rodent brain. Using in vivo lineage traci...

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Literature Corpus work: cda00f80-4bdd-58e8-8fa6-a0ab66c4f5a5
DOI: 10.1101/2020.09.22.307058

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