Article

An early cell shape transition drives evolutionary expansion of the human forebrain

2020-07-04

Abstract excerpt

The human brain has undergone rapid expansion since humans diverged from other great apes, but the mechanism of this human-specific enlargement is still unknown. Here, we use cerebral organoids derived from human, gorilla and chimpanzee cells to study developmental mechanisms driving evolutionary brain expansion. We find that the differentiation of neuroepithelial cells to neurogenic radial glia is a protracted pr...

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Literature Corpus work: fbb773a7-78d4-5bae-866c-1fb0626acc2a
DOI: 10.1101/2020.07.04.188078

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