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Article

Preleukemic and leukemic evolution at the stem cell level

5 Dec 2020

Abstract excerpt

Hematological malignancies are an aggregate of diverse populations of cells that arise following a complex process of clonal evolution and selection. Recent approaches have facilitated the study of clonal populations and their evolution over time across multiple phenotypic cell populations. In this review, we present current concepts on the role of clonal evolution in leukemic initiation, disease progression, and...

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Identifiers

PMID: 33275656
DOI: 10.1182/blood.2019004397

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