Article

Deciphering the determinants of recombinant protein yield across the human secretome

2022-12-14

Abstract excerpt

Mammalian cells are critical hosts for the production of most therapeutic proteins and many proteins for biomedical research. While cell line engineering and bioprocess optimization have yielded high protein titers of some recombinant proteins, many proteins remain difficult to express. Here, we decipher the factors influencing yields in Chinese hamster ovary (CHO) cells as they produce 2165 different proteins fro...

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Literature Corpus work: 362db393-373d-556b-98db-a52598e657ef
DOI: 10.1101/2022.12.12.520152

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