Article
Sustained productivity in recombinant Chinese hamster ovary (CHO) cell lines: proteome analysis of the molecular basis for a process-related phenotype.
BMC biotechnology - 24 Jul 2011
Meleady Paula, Doolan Padraig, Henry Michael, Barron Niall, Keenan Joanne, O'Sullivan Finbar, Clarke Colin, Gammell Patrick, Melville Mark W, Leonard Mark, Clynes Martin
Abstract excerpt
BACKGROUND: The ability of mammalian cell lines to sustain cell specific productivity (Qp) over the full duration of bioprocess culture is a highly desirable phenotype, but the molecular basis for sustainable productivity has not been previously investigated in detail. In order to identify proteins that may be associated with a sustained productivity phenotype, we have conducted a proteomic profiling analysis of...
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