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ATF6β‐based fine‐tuning of the unfolded protein response enhances therapeutic antibody productivity of Chinese hamster ovary cells

6 Feb 2017

Abstract excerpt

The dynamics of protein folding and secretion are key issues in improving the productivity and robustness of Chinese hamster ovary (CHO) producer cells. High recombinant protein secretion in CHO producer clones triggers the activation of the unfolded protein response (UPR), an intracellular response to the accumulation of unfolded and misfolded proteins in the endoplasmic reticulum (ER). We previously reported...

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PMID: 28165157
DOI: 10.1002/bit.26263

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