Insights into the prevalence and underlying causes of clonal variation through transcriptomic analysis in Pichia pastoris.

Abstract excerpt

Clonal variation, wherein a range of specific productivities of secreted proteins are observed from supposedly identical transformants, is an accepted aspect of working with Pichia pastoris. It means that a significant number of transformants need to be tested to obtain a representative sample, and in commercial protein production, companies regularly screen thousands of transformants to select for the highest...

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