Large-scale transcriptomics analysis reveals a novel stress biomarker in CHO cells producing difficult to express mAbs

Abstract excerpt

Monoclonal antibodies (mAbs) are considered one of the most game-changing products of the biopharmaceutical industry. The introduction of several diverse and complex formats consisting of several polypeptide chains and engineered with multiple antigen-binding domains has made the manufacturability process particularly challenging, especially in the context of assessing expression levels and yields of the formats....

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