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Article

Elucidation of the CHO Super-Ome (CHO-SO) by Proteoinformatics

29 Sept 2015

Abstract excerpt

Chinese hamster ovary (CHO) cells are the preferred host cell line for manufacturing a variety of complex biotherapeutic drugs including monoclonal antibodies. We performed a proteomics and bioinformatics analysis on the spent medium from adherent CHO cells. Supernatant from CHO-K1 culture was collected and subjected to in-solution digestion followed by LC/LC-MS/MS analysis, which allowed the identification of...

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PMID: 26418914
DOI: 10.1021/acs.jproteome.5b00588

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