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RNA‐Seq Highlights High Clonal Variation in Monoclonal Antibody Producing CHO Cells

9 Jan 2018

Abstract excerpt

The development of next-generation sequencing technologies has opened new opportunities to better characterize complex eukaryotic cells. Chinese hamster ovary (CHO) cells play a primary role in therapeutic protein production, with currently five of the top ten blockbuster drugs produced in CHO. However, engineering superior CHO cells with improved production features has had limited success to date and cell lines...

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PMID: 29316330
DOI: 10.1002/biot.201700231

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