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Article

Extraordinary molecular evolution in the PRDM9 fertility gene.

PloS one - 30 Dec 2009

Thomas James H, Emerson Ryan O, Shendure Jay

Abstract excerpt

Recent work indicates that allelic incompatibility in the mouse PRDM9 (Meisetz) gene can cause hybrid male sterility, contributing to genetic isolation and potentially speciation. The only phenotype of mouse PRDM9 knockouts is a meiosis I block that causes sterility in both sexes. The PRDM9 gene...

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Source

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Identifiers

PMID: 20041164
DOI: 10.1371/journal.pone.0008505
PMCID: PMC2794550

Genes

PRDM9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20041164-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Extraordinary molecular evolution in the PRDM9 fertility gene.PMID 20041164Read ↗

Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice.Semantic proximity Read ↗

Bridging the gap between the evolutionary dynamics and the molecular mechanisms of meiosis: A model based exploration of the PRDM9 intra-genomic Red Queen.Semantic proximity Read ↗

Zinc Finger Domain of the PRDM9 Gene on Chromosome 1 Exhibits High Diversity in Ruminants but Its Paralog PRDM7 Contains Multiple Disruptive Mutations.Semantic proximity Read ↗

Prdm9 controls activation of mammalian recombination hotspots.Semantic proximity Read ↗

Primate evolution of the recombination regulator PRDM9.Semantic proximity Read ↗

Evolution of the recombination regulator PRDM9 in minke whales.Semantic proximity Read ↗

PRDM9 variation strongly influences recombination hot-spot activity and meiotic instability in humans.Semantic proximity Read ↗

PRDM9 is a major determinant of meiotic recombination hotspots in humans and mice.Semantic proximity Read ↗

Natural variation in the zinc-finger-encoding exon of Prdm9 affects hybrid sterility phenotypes in mice.Semantic proximity Read ↗

Evidence of positive selection and concerted evolution in the rapidly evolving PRDM9 zinc finger domain in goats and sheep.Semantic proximity Read ↗

<i>PRDM9</i> losses in vertebrates are coupled to those of paralogs <i>ZCWPW1</i> and <i>ZCWPW2</i>Semantic proximity Read ↗

Human PRDM9 can bind and activate promoters, and other zinc-finger proteins associate with reduced recombination in <i>cis</i>Semantic proximity Read ↗

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