Article

Cell-type targeted CRISPR/Cas9 Clock knockdown in mouse VTA dopamine neurons alter sleep, behavior, and cellular excitability

2026-06-05

Abstract excerpt

<h4>Summary</h4> Bipolar disorder (BD) is a severe psychiatric disease characterized by recurrent mania, depression, and circadian rhythm disruption. Among circadian regulators implicated in mood-related dysfunction, Clock has emerged as a particularly strong mechanistic candidate. However, cell type-specific functions of Clock within mood-relevant circuits remain incompletely defined. Here, we developed and appl...

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Literature Corpus work: 3600bad0-16ca-50d3-a588-c1648b7fb8df
DOI: 10.64898/2026.06.03.730017

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